Aging & Neuroepidemiology

  • Dr Jim Anthony


    faculty-icon  Faculty page |  JimLab Research


    NIMH Epidemiologic Catchment Area Surveys and Long-Term Followup

    Established ~40 years ago, the original purpose of the five-site multi-wave Epidemiologic Catchment Area (ECA) program was focused on estimation of both incidence and prevalence of specific mental disorders and use of general and mental health services. The work scope expanded to encompass multiple organ systems and diseases. JA first was responsible for drawing the Baltimore sample (n=3481 adults of all ages) and coordinating the multi-site assessment protocol with four other ECA sites, as well as other facets of study design and conduct, including creation of five site public use datasets that are stored at ICPSR. I then became ECA Principal Investigator (with WW Eaton) from the mid-1980s through the mid-2000s, during two additional followup waves (including buccal and blood specimen collection), and I retain heritage PI-related privileges. By mutual agreement, Johns Hopkins University continues as sponsoring institution, and we access the ECA data via Data Use Agreements now administered by JHU Professor Adam Spira as ECA PI. Our most recent ECA project involved linking National Death Index with ECA records as illustrated in several recent publications cited below. Current fieldwork, now underway, includes collection and lab analysis of new buccal and blood specimens, as well as health information, for studies of inflammation, aging, and epigenetic processes. At present, five waves of data are available for the ~600 survivors, now mean age 72 years (range: 56-100).

  • Dr Honglei Chen


    faculty-icon  Faculty page


    R01AG071517, NIA (PI: Honglei Chen)                                              06/15/2022 – 03/01/2027

    Poor sense of smell and the health of older adults

    By exploiting extensive prospective data from the Health ABC and ARIC-Neurocognitive studies, we aim to answer two novel and clinically-significant questions: 1) What adverse health outcomes can a poor sense of smell in older adults potentially herald, in addition to neurodegenerative diseases? 2) Is poor olfaction a marker of accelerated aging?


    R01ES029227, NIEHS, (PI: Honglei Chen)                                       02/01/2019 – 01/31/2024

    The PASS Study - Pesticides, olfaction, and neurodegeneration among US farmers

    The goal is to evaluate exposures to pesticides in relation to poor olfaction and how they may contribute to prodromal neurodegeneration in older farmers. In this project, we enrolled ~2,500 male farmers of the Agricultural Health Study, selected based on their self-reported sense of smell. We tested their olfaction using the Brief Smell Identification Test and assessed other prodromal symptoms of neurodegeneration, motor symptoms, and cognitive status.


    W81XWH-17-1-0536 / PF-IMP-1825, (multi-PI)                                 09/01/2017-08/31/2022

    Airborne pollutants as triggers of Parkinson’s disease via the olfactory system

    The goal is to assess whether ambient air pollutants contribute to the prodromal development of Parkinson’s disease. In this project, we enrolled ~3,500 women of the Sister Study, selected based on their self-reported sense of smell and age. We tested their olfaction using the Brief Smell Identification Test and conducted genomewide genotyping using the Neuroarray chip. Data on other prodromal symptoms of neurodegeneration, motor symptoms, and cognitive status were collected as part of the Sister Study’s cohort-wide follow-up surveys.


    Prospective studies of Parkinson’s disease

    (PI: Honglei Chen, NIEHS 1ZIAES101986, 2006-2016)

    Using data from the NIH-AARP Diet and Health Study and several other cohorts, we investigate genetic and environmental risk factors for Parkinson’s disease. 


 aging neuro epi