Infectious Disease Epidemiology

infectious disease

 

faculty-icon  Dr. Joseph Gardiner

 

Treating Brain Swelling in Pediatric Cerebral Malaria

An NIAID-sponsored study lead by Dr. Terrie Taylor, seeks to examine strategies to treat children with cerebral malaria (CM). Malawian children with CM and severely increased brain volumes on screening brain magnetic resonance imaging with be randomized to one of three study arms: standard of care (SOC); SOC supplemented by intravenous hypertonic saline; SOC supplemented by early intubation and mechanical ventilation. The primary outcome is failure of the first treatment to which the child is assigned or death, whichever comes first. Practical considerations in conducting the study, and the annual 6-month malaria season were incorporated in a group sequential trial design with early stopping for either efficacy or futility. Dr. Joseph Gardiner serves as co-investigator and Study Biostatistician on this study.

 


 

faculty-icon  Dr. Lixin Zhang

 

Antibiotic Prophylaxis and Neonatal Sepsis

The goal of this project is to understand the changing sepsis epidemiology in the era of widespread use of intrapartum antibiotic prophylaxis and the role of infant microbiome in sepsis risk. A birth cohort recruited from a study site in Indonesia with a high incidence of sepsis is being used to achieve this goal.  The project is led by Dr. Lixin Zhang and Ph.D. candidate Ariesti Karmila.